Kansas, Arizona Football Open as Favorites and Underdogs in Big 12 Matchups

The Kansas Jayhawks will host the Cincinnati Bearcats in their second consecutive home game as they aim for a 2-0 start in Big 12 play, with FanDuel Sportsbook setting the Jayhawks as 4.5-point favorites. Meanwhile, Illinois is set to face USC, where the Trojans are favored by 5.5 points, reflecting Illinois' struggles following a heavy loss to Indiana. Arizona Wildcats, undefeated and strong against the spread this season, will open their Big 12 schedule as 6.5 to 7.5-point underdogs against the 12th-ranked Iowa State Cyclones, with the game marking their first meeting since 1968. Arizona's recent performance off bye weeks has been solid, and the matchup is highly anticipated given Iowa State's top ranking in the conference. The UC Davis Aggies are scheduled to visit Northern Arizona Lumberjacks, continuing their Big Sky Conference play. Overall, Big 12 and other college football conference games are drawing significant betting interest as teams test their early-season form.