Minnesota Vikings wide receiver Jordan Addison has been ruled out for Sunday's game against the San Francisco 49ers due to a right ankle injury sustained in last week's win over the New York Giants. Head coach Kevin O'Connell confirmed Addison's absence and noted that his timeline for return is uncertain. Jalen Nailor will serve as the WR2 behind Justin Jefferson, with Brandon Powell, Trent Sherfield, and Trishton Jackson providing additional depth. The Vikings also have several key players listed as questionable, including safety Harrison Smith with a hip injury, right tackle Brian O'Neill with an elbow injury, and right guard Ed Ingram with a triceps injury. These injuries could impact the team's performance against the 49ers, especially considering the potential matchups against strong opponents like Nick Bosa.