The Arizona Wildcats kicked off their season with a commanding 61-39 victory over the New Mexico Lobos, highlighted by wide receiver Tetairoa McMillan's record-setting performance. McMillan caught 10 passes for a school-record 304 yards and four touchdowns, breaking a previous record that stood since 1996. Quarterback Noah Fifita contributed significantly, completing 19 of 31 passes for 422 yards, while New Mexico's Devon Dampier showcased his athleticism by accounting for five touchdowns. Despite the win, Arizona's defense struggled, allowing New Mexico to remain competitive in the first half. The Wildcats also faced issues with penalties, which coach Brent Brennan will need to address moving forward. This game marked Arizona's first contest as part of the Big 12 Conference.