49ers Injury Hits Week 2 Odds Against Saints

The San Francisco 49ers will face the New Orleans Saints in a closely watched NFC matchup impacted heavily by injuries. The 49ers are without starting quarterback Brock Purdy, who is sidelined with toe and shoulder injuries and expected to miss multiple weeks, leading Mac Jones to start in his place. Key offensive players George Kittle and Jauan Jennings are also injured, while running back Christian McCaffrey has returned to full participation. The Saints are dealing with injuries on their defensive line and secondary, including absences by Chase Young and Julian Blackmon. These injury developments have shifted betting odds significantly, with the 49ers' favored spread dropping from around -6.5 to about -3, reflecting concerns about their offensive capabilities without Purdy. Both teams are expected to engage in a physical, possession-oriented game where San Francisco's success depends on protecting their backup quarterback and generating explosive plays, while New Orleans aims to maintain balance and capitalize on third-down situations.