The Louisville Cardinals are set to face the unbeaten Miami Hurricanes on Saturday, opening as 4-point underdogs. This marks only the fifth time under head coach Jeff Brohm that Louisville has been an underdog, with a previous home loss to Notre Dame this season. Meanwhile, the Arizona Cardinals are also facing challenges, opening as 2.5-point home underdogs against the Los Angeles Chargers, after a season of ups and downs. The Miami Dolphins, coming off a bye week, are preparing to face the Colts, but will be without quarterback Tua Tagovailoa due to injury. In college football, the Kentucky Wildcats shifted from favorites to underdogs against Florida after a loss to Vanderbilt, with the Gators now favored by one to two points. Each team faces critical matchups that could impact their season trajectories.