The Buffalo Bills are set to kick off their season against the Arizona Cardinals, with an emphasis on stopping the run game and defending the middle of the field to mitigate threats from Cardinals' players like James Conner and Trey McBride. The Bills will face challenges due to injuries, notably the absence of linebacker Matt Milano, which may weaken their pass defense against tight ends. Arizona's rookie wide receiver Marvin Harrison Jr. is anticipated to have a breakout game, with high expectations set for his debut alongside quarterback Kyler Murray. Bills' offensive coordinator Joe Brady plans to implement a balanced approach, leaning on star running back James Cook while allowing Josh Allen to distribute the ball among new weapons. The team's mantra of