The San Francisco 49ers have activated All-Pro safety Talanoa Hufanga from the active/PUP list, avoiding a mandatory four-game absence to start the season. Despite this, Hufanga has not yet participated in practices since his ACL tear last year, and his availability for the season opener against the Jets remains uncertain. He recorded 52 tackles and three interceptions in 10 games last season. If Hufanga is unable to play, George Odum or rookie Malik Mustapha are expected to step in as starting strong safety. Other notable roster moves include placing running back Elijah Mitchell on season-ending Injured Reserve and the uncertainty around starters Dre Greenlaw, Trent Williams, and Brandon Aiyuk due to injuries and contract issues.