The LA Chargers (1-0) are set to face the Carolina Panthers (0-1) in a Week 2 matchup at Bank of America Stadium, with the Chargers coming off a confident 22-10 victory over the Raiders. The Chargers displayed a strong running game, averaging 176 yards, while the Panthers struggled significantly in their previous game, suffering a 47-10 loss to the Saints, with only 58 rushing yards. Oddsmakers have made the Chargers 3.5-point favorites, but historical trends suggest the Panthers could be competitive, having won the last four meetings between the teams. Chargers' coach Jim Harbaugh has expressed the need for improvement in discipline and red-zone efficiency despite their opening win. The Panthers will need to enhance their offensive performance if they hope to challenge the Chargers effectively in this contest. Kickoff is scheduled for 1 p.m. ET on CBS.