Washington State dominated Texas Tech with a 37-16 victory, highlighted by quarterback John Mateer's performance, including a 68-yard run and two touchdowns. Texas Tech struggled without star running back Tahj Brooks and suffered additional injuries during the game, limiting their effectiveness. Meanwhile, Arkansas suffered a heartbreaking 39-31 double overtime loss to No. 17 Oklahoma State, despite outgaining the Cowboys significantly and leading at halftime; turnovers and missed field goals proved costly. Gustavus faced a tough start to the season with a 40-7 defeat against No. 24 Whitworth, plagued by seven turnovers, including five interceptions. Weber State lost to Washington 35-3, failing to score until the third quarter despite a promising start. Duquesne also struggled in their opener, falling 49-10 to Toledo, with turnovers derailing their offensive efforts.