FDA Warns Severe Itching Risk After Stopping OTC Allergy Medications

The FDA has issued a warning regarding a rare but severe side effect involving intense itching (pruritus) that can occur after stopping long-term use of over-the-counter allergy medications cetirizine (Zyrtec) and levocetirizine (Xyzal). This reaction, reported in over 200 cases mostly in the U.S., typically appears within days after discontinuation and sometimes requires medical intervention. The FDA is requiring manufacturers to add warnings about this risk to prescription and over-the-counter labeling, advising patients to consult their doctors if they experience severe itching after stopping these medications. Separately, researchers at Monash University have developed an algorithm to identify and help de-label incorrect penicillin allergy claims, which often arise from side effects rather than true immune reactions. This initiative aims to reduce inappropriate antibiotic prescribing and combat antimicrobial resistance, with community pharmacists playing a key role in educating patients about their allergy status. Both developments highlight ongoing efforts to improve medication safety and patient outcomes related to allergy treatments.