2025 College Football Season Betting Lines Show Key Rivalries, Championship Contenders

The 2025 college football season features several notable matchups and betting lines with prominent teams vying for top positions. Penn State is ranked No. 3 in the USA Today preseason coaches poll and is tied at +700 odds with Georgia to win the College Football Playoff, trailing only Texas and Ohio State. Oregon, the defending Big Ten champion, will open their season as 25.5-point favorites against Montana State, aiming to extend their strong home winning streak, and they are 4.5-point underdogs at Penn State later in the season. USC starts their 2025 campaign as heavy home favorites against Missouri State with a 34.5-point spread, while Michigan is favored by 8.5 points over Michigan State in their October rivalry game. High-profile games to watch include Oregon vs. Penn State at Beaver Stadium and Oregon vs. USC at home, with betting lines reflecting the competitive nature of these contests and the strong defensive reputations of the teams involved.