During the ManningCast for the San Francisco 49ers vs. New York Jets game, Peyton Manning expressed frustration with 49ers wide receiver Brandon Aiyuk after he dropped a touchdown pass. Manning criticized Aiyuk for missing training camp, emphasizing the importance of practice and conditioning for players, stating, "Get signed, get in training camp, there's a reason for training camp, you need it!" Eli Manning attempted to offer a more measured perspective, suggesting Aiyuk was simply rusty, but Peyton remained adamant about the need for early contract resolutions to avoid such issues. Aiyuk had missed all of training camp while negotiating a four-year, $120 million contract before finally signing on September 3. Social media reactions were mixed, with some agreeing with Peyton's stance on the significance of practice. Manning also referenced his own experience with teammate Edgerrin James, underscoring the long-term impact of holdouts on performance.