Sam Darnold led the Minnesota Vikings to a commanding 28-6 victory over the New York Giants in their season opener at MetLife Stadium. Darnold threw for 208 yards and two touchdowns, with notable performances from Justin Jefferson and Jalen Nailor. The Vikings' defense, highlighted by Andrew Van Ginkel's interception return for a touchdown, stifled the Giants' offense, which struggled, particularly QB Daniel Jones, who threw two interceptions. The Giants' defense had a strong start but was unable to sustain momentum. Meanwhile, the 49ers face their own challenges ahead of their game against the Jets, with key players like Christian McCaffrey listed as questionable and Yetur Gross-Matos ruled out due to injuries.