San Francisco 49ers Suffer First Season Loss to Jacksonville Jaguars 26-21 Amid Key Injuries

The San Francisco 49ers suffered a 26-21 loss to the Jacksonville Jaguars, marking their first defeat of the 2025 season, highlighted by turnovers and defensive struggles without star pass rusher Nick Bosa. Quarterback Brock Purdy returned from injury but threw two interceptions and lost a fumble, while the offense struggled with dropped passes and an ineffective running game that remains without a touchdown this season. Despite the loss, Christian McCaffrey led the receiving corps with six catches for 92 yards and a touchdown, and tight end Jake Tonges contributed with two touchdowns on the season amid the absence of George Kittle. The 49ers' defense was unable to pressure the Jaguars' quarterback or prevent big special teams plays, including an 87-yard punt return touchdown, continuing a streak without interceptions. Coach Kyle Shanahan's strategic decisions, including a failed challenge and conservative fourth-down choices, were also scrutinized in the loss. Still, the team remains resilient early in the season despite injuries and roster changes, maintaining a competitive outlook as they prepare to face the Rams on Thursday Night Football.