Cleveland Browns Seek Road Breakthrough Against Detroit Lions in NFL Week 4 Clash

The Detroit Lions (2-1) will host the Cleveland Browns (1-2) at Ford Field on September 28, 2025, in a game where the Lions are favored both by betting odds and recent performance. The Lions rank 13th in defense but boast the third-best offense in the NFL, while the Browns struggle offensively but show resilience, recently eking out a narrow 13-10 win over the Green Bay Packers. Key Browns players like Myles Garrett and kicker Andre Szmyt have shown toughness and determination, contributing to their defensive strength despite the team’s overall inconsistency. The Lions have an undefeated home record this season and have demonstrated strong offensive capabilities, including a 52-21 victory over the Bears. Betting odds heavily favor the Lions with a -483 moneyline versus the Browns at +368, and a 9-point spread in favor of Detroit. Both teams present challenges, but the Lions’ home advantage and offensive production make them the clear favorites going into this matchup.