Romanian qualifier Elena-Gabriela Ruse achieved a major upset by defeating Wimbledon champion Barbora Krejcikova in straight sets, 6-4, 7-5, in the second round of the US Open 2024, marking Ruse's first advancement to the third round of a Grand Slam. Krejcikova struggled with her form, having not played on hard courts since February. In other matches, defending champions Coco Gauff and Novak Djokovic advanced, with Gauff defeating Tatjana Maria 6-4, 6-0. Notable wins included Taylor Fritz over Matteo Berrettini and Andrey Rublev's comeback against Arthur Rinderknech. Additionally, Peyton Stearns defeated 12th seed Daria Kasatkina, marking another early exit for the Russian player.