The San Francisco 49ers are facing a significant injury crisis ahead of their Week 3 matchup against the Los Angeles Rams, with tight end George Kittle missing practice due to a hamstring issue. This adds to the woes of the team, which is already without running back Christian McCaffrey, who is on injured reserve due to Achilles tendinitis, and wide receiver Deebo Samuel, sidelined for at least two weeks with a calf injury. Following a loss to the Minnesota Vikings, the 49ers are looking to rebound but will have to rely on depth players like Eric Saubert and Jake Tonges at tight end if Kittle cannot play. Meanwhile, the Rams are also dealing with their own injury challenges, including key players like Cooper Kupp and Jonah Jackson potentially out for the foreseeable future. Both teams are navigating early season struggles with injuries, raising concerns about their respective offensive capabilities. The 49ers will need major contributions from players like Brandon Aiyuk and Brock Purdy to maintain their competitive edge against the Rams.