The San Francisco 49ers concluded their preseason with a 24-24 tie against the Las Vegas Raiders. Brock Purdy, who threw a red-zone interception, and several key starters made their preseason debuts, although notable players like Christian McCaffrey, Trent Williams, and Brandon Aiyuk were absent due to injuries and contract disputes. The 49ers are dealing with several injuries, including Talanoa Hufanga, who might start the season on the Physically Unable to Perform List. Rookie Isaac Guerendo is expected to return to practice after a hamstring injury, offering valuable reps due to other running backs being sidelined. The regular season opener for the 49ers is set for September 9 against the New York Jets.