A recent study suggests that combining weight loss drugs like Ozempic with antidepressants may increase the risk of suicidal thoughts, although experts criticize the study's weak evidence and limitations. The study analyzed a WHO database and found 107 cases linked to semaglutide and 162 to liraglutide, but the small sample size limits the findings' reliability. Researchers urge further investigation into whether additional precautions are needed for patients with mental health issues. Meanwhile, experts highlight side effects such as hair loss and rapid weight regain after stopping these drugs, emphasizing the need for balanced diets and consistent physical activity. The financial burden of self-funding weight loss drugs is also significant, with some users spending thousands without long-term success. This raises concerns about the sustainability and overall efficacy of these treatments.