Sandy Ryan will defend her WBO welterweight title against Mikaela Mayer on September 27 at Madison Square Garden, marking a significant bout for both fighters. Ryan, who has a record of 8-1, is making her second title defense, while Mayer, a former champion at super-featherweight with a record of 19-2, seeks to reclaim her status in a new weight class. The fight will also feature rising stars Xander Zayas and Bruce Carrington on the undercard. Both fighters expressed excitement about the opportunity, with Ryan emphasizing her readiness to defend her title and Mayer expressing gratitude for the fight's arrangements. Bob Arum of Top Rank stated that this matchup features two of the best pound-for-pound fighters, and the winner will assert dominance in the welterweight division. The event will be broadcast live on ESPN and other platforms.