The Minnesota Vikings improved to 2-0 with a 23-17 victory over the San Francisco 49ers, but suffered a significant blow with the loss of star receiver Justin Jefferson due to a right quad injury sustained in the third quarter. Jefferson, who had four receptions for 133 yards and a touchdown, was helped off the field but managed to walk to the locker room for further evaluation. Minnesota is now without its top two receivers, as Jordan Addison was inactive due to an ankle injury. The Vikings made crucial fourth down stops and capitalized on special teams plays, with C.J. Ham blocking a punt that led to an early field goal. Sam Darnold threw for 268 yards and two touchdowns, guiding the team to its first 2-0 start since 2016. The severity of Jefferson's injury remains uncertain, prompting concerns about its impact on the Vikings' season.