49ers Start Mac Jones Amid Injuries, Trent Williams Uncertain vs Saints

The San Francisco 49ers face significant injury challenges heading into their Week 2 game against the New Orleans Saints, with quarterback Brock Purdy and tight end George Kittle ruled out, and All-Pro left tackle Trent Williams and wide receiver Jauan Jennings listed as questionable. Purdy is sidelined due to turf toe and shoulder injuries, with backup Mac Jones expected to start, bringing previous starting experience from New England. Williams, who has been managing a knee issue, participated in limited practice and is expected to play, despite recent struggles in pass blocking. Jennings, recovering from a left shoulder injury sustained in Week 1, returned to limited practice and is expected to suit up. The 49ers aim to start the season 2-0, a start that has historically led to deep playoff runs under coach Kyle Shanahan. The Saints, led by new coach Kellen Moore, are also dealing with injuries, including the season-ending loss of safety Julian Blackmon, but remain a formidable opponent.