49ers' Christian McCaffrey Added to Injury Report with Calf Issue Ahead of Season Opener

San Francisco 49ers running back Christian McCaffrey was added to the team's injury report with a calf issue just days before the 2025 season opener, raising concerns due to his injury-plagued 2024 season. McCaffrey, who had no disclosed health problems during the 2025 training camp, was limited in practice and did not participate fully, sparking fears that the calf injury could be related to his previous bilateral Achilles tendinitis, which caused him to miss the first eight games last year. Despite looking healthy throughout the offseason and training camp, McCaffrey's history of recurring injuries, including a torn knee ligament in 2024, suggests that this latest setback could threaten his availability and performance. Teammates and analysts express cautious optimism but acknowledge the difficulty McCaffrey faces in maintaining his explosive playing style given his physical limitations. The 49ers, coming off a disappointing 2024 season marred by injuries, now face uncertainty about their star running back's readiness for the opener against the Seattle Seahawks. This development is a considerable blow to both the team and fantasy football enthusiasts, as McCaffrey remains a pivotal figure in San Francisco's offense.