Ryan Reynolds Replaced by Neil Patrick Harris in Marvel Deadpool VR

Ryan Reynolds, long synonymous with the role of Deadpool, has humorously reacted to being replaced by Neil Patrick Harris as the voice of Deadpool in the upcoming Marvel's Deadpool VR game for Meta Quest 3 and 3S. Announced at Summer Games Fest 2025, the game marks the first time Reynolds will not voice the character in a Deadpool project since 2009, prompting him to release a parody video referencing Harris's role on Doogie Howser, M.D., where Reynolds jokingly laments having his signature role "stolen." Despite the casting change, Reynolds praised Harris as an amazing actor with a nurturing voice, and fans have responded positively to Reynolds's comedic take on the news. The move surprised many fans who expected Reynolds to continue voicing Deadpool, but the playful promotional approach, including Reynolds’s involvement in the marketing, has helped ease the transition. The connection between the actors is further highlighted by Robyn Lively, Harris's former co-star and sister to Reynolds’s wife Blake Lively, appearing in Reynolds’s parody video. Overall, while fans are mixed on the casting, the situation showcases Reynolds’s trademark humor and endorsement of Harris’s new role.