Kali Rocha is set to return as Dr. Sydney Heron in Grey's Anatomy for the show's 21st season, nearly 17 years after her last appearance. Heron, who first appeared as a substitute chief resident in Season 2, will appear in three episodes this season, although details of her storyline remain undisclosed. The new season will also welcome back series regular Meredith Grey, portrayed by Ellen Pompeo, who is set to appear in at least seven episodes, and Scott Speedman as Nick Marsh. Meanwhile, Jake Borelli (Dr. Levi Schmitt) and Midori Francis (Dr. Mika Yasuda) are departing the show, with Michael Thomas Grant joining the cast as a new character, James. The season premiere is scheduled for September 26, 2024, and promises to bring significant changes to the familiar dynamics at Grey Sloan Memorial Hospital.