Bills, Chargers, Chiefs Headline 2025 AFC Storylines

The Buffalo Bills enter the 2025 NFL season as the only team favored in all 17 games and have the league’s best playoff odds at -750, highlighting their strong position to return to the postseason. Their offensive improvements, fortified defense, and favorable schedule contribute to their status as favorites. In the AFC West, the Los Angeles Chargers, led by Jim Harbaugh, are viewed as potential challengers with projections ranging from 8-9 to 13-4, but remain underdogs to the Kansas City Chiefs, who hold an 18-3 edge in the rivalry since 2014. The Chargers are especially motivated to end their losing streak against the Chiefs, with several recent close games providing optimism. The Chiefs, led by Patrick Mahomes, continue to be seen as the division’s dominant force, while the Chargers’ roster upgrades could make them a disruptive contender. Analysts remain skeptical that any AFC West team is ready to surpass the Chiefs in 2025.