The Houston Texans secured a narrow 29-27 victory over the Indianapolis Colts in their season opener, powered by key performances from new acquisitions Stefon Diggs and Joe Mixon. Diggs caught two touchdown passes while Mixon rushed for 159 yards and a touchdown, showcasing the Texans' revamped offense. Quarterback C.J. Stroud was efficient, completing 24 of 32 passes for 234 yards and two touchdowns. Nico Collins also contributed significantly with six receptions for 117 yards. Despite a strong showing by Colts' quarterback Anthony Richardson, who threw two long touchdown passes and rushed for another, the Texans managed to hold on for the win. This victory marks Houston's second straight road win in the series and extends the Colts' opening day winless streak to 11 games.