Louisville, James Madison Prepare for Crucial 2025 Football Clash

The University of Louisville football team is preparing to face James Madison in their second game of the 2025 season, with the Cardinals favored by 13.5 points and looking to build on their strong season opener. Louisville's quarterback Miller Moss, a confident transfer from USC, is expected to have a standout performance under the Friday night lights. Head coach Jeff Brohm emphasizes the need for discipline, execution, and reducing penalties and turnovers to overcome a well-coached and versatile James Madison team, which features a fast-paced offense led by quarterback Alonza Barnett II and key running back George Pettaway. Louisville faces some injury challenges with key players unlikely or uncertain to play, while James Madison appears healthier and loaded with talent despite being a Group of Five school. The game will test Louisville's defense against James Madison's dynamic offense, and the Cardinals will rely on strong fan support at L&N Stadium to maintain their momentum. Both teams are expected to bring intensity and strategic adjustments, making this a critical matchup early in the season.