Christina Applegate's 13-year-old daughter, Sadie Grace LeNoble, has been diagnosed with Postural Orthostatic Tachycardia Syndrome (POTS), a condition affecting the autonomic nervous system that causes dizziness, fatigue, and a rapid heart rate upon standing. Sadie shared her struggle with POTS, including frequent trips to the school nurse and misunderstandings about her condition. She also discussed the emotional impact of watching her mother battle multiple sclerosis (MS) since 2021. Applegate, who feels guilty about her own health limitations, expressed immense pride in her daughter. Despite the challenges, their close bond and mutual support have been a source of strength for both.