Korea University Identifies Blood Protein Spreading Aging Systemically

A groundbreaking study by a Korean research team led by Professor Ok Hee Jeon at Korea University has uncovered that aging can spread systemically through the bloodstream via a redox-sensitive protein called reduced HMGB1 (ReHMGB1). This protein, secreted by senescent cells, acts as a molecular messenger transmitting senescence signals to distant tissues, impairing regeneration and muscle function. Experimental models showed that ReHMGB1—but not its oxidized form—induces senescence markers and inflammatory factors in various human cell types and mice, contributing to age-related tissue dysfunction. Importantly, blocking ReHMGB1 with antibodies in middle-aged mice reduced senescence markers, enhanced muscle regeneration, and improved physical performance, highlighting a promising therapeutic target to slow or reverse aging-related decline. The discovery provides the first clear evidence of systemic aging transmission via the bloodstream and suggests new avenues for interventions against age-associated diseases. This research was published in the journal Metabolism – Clinical and Experimental and represents a significant advance in understanding how cellular aging spreads beyond local tissues.