The Buffalo Bills are set to face the Jacksonville Jaguars at home, seeking to improve to 3-0 despite their recent struggles against Jacksonville, having lost in the last two encounters. The Jaguars, currently winless and desperate for a victory, have historically posed challenges for the Bills, with a 1-3 record against them since Sean McDermott took over as head coach. Key players like Josh Allen and Trevor Lawrence will be under scrutiny as both teams aim to turn their seasons around. The rivalry has deep roots, dating back to their first clash in 1995, where the Bills notably lost in a critical playoff matchup. Recent performances highlight the Jaguars' potential to upset, as they've been competitive despite their record. The game promises to be a pivotal moment for both teams in their respective seasons.