The highly anticipated film 'Deadpool & Wolverine' is set to make a historic box office debut, with projections estimating a record-breaking $360 million opening weekend globally. Directed by Shawn Levy and starring Ryan Reynolds and Hugh Jackman, the film is a hyperactive, self-referential adventure that pays homage to the last quarter-century of Marvel blockbusters produced by Twentieth Century Fox. Critics and early viewers have praised its mix of humor, action, and emotional depth, marking it as a potential game-changer for the Marvel Cinematic Universe (MCU). The film also signifies the beginning of a new 'Mutant Era' in the MCU, as confirmed by Marvel President Kevin Feige. With its strong advance ticket sales and positive pre-release buzz, 'Deadpool & Wolverine' is poised to be one of the biggest R-rated films of all time.