Louisville Opens as 26.5-Point Favorite vs Bowling Green for 2025 Clash

The Louisville Cardinals (2-0) will host the Bowling Green Falcons (2-1) on Saturday, September 20, 2025, with Louisville favored by approximately 26.5 points and the over/under around 51.5 points. Louisville boasts a strong defense, ranking 7th nationally in passing yards allowed, coupled with a potent offense led by standout running back Isaac Brown, making them the clear favorite to extend their undefeated streak. Bowling Green, coached by Eddie George, features a controlling style with a strong time of possession and an effective rushing attack but has inconsistencies on offense and will rely on special teams and Brown's explosive runs to challenge Louisville’s defense. Despite Louisville's dominance and a high winning probability, Bowling Green's ability to sustain drives and capitalize on scoring opportunities could keep the game competitive, especially as Louisville has struggled against the spread at home this season. Louisville’s head coach Jeff Brohm, known for strong performances after byes, will aim to address offensive concerns before conference play begins. Overall, experts predict Louisville to secure a convincing win while Bowling Green may make key plays to influence the total score.