In a dominant 35-10 victory over the Buffalo Bills, Derrick Henry set a franchise record with an 87-yard touchdown run on the Ravens' first play, leading Baltimore to its second straight win and handing Buffalo its first loss of the season. Henry rushed for 199 yards on 24 carries and caught a touchdown pass, falling just short of a 200-yard game, which would have set a new NFL record for most career 200-yard rushing games. Lamar Jackson contributed significantly with two touchdown passes and a rushing touchdown, guiding the Ravens to a commanding 21-3 halftime lead. Despite a brief resurgence from the Bills in the second half, including a touchdown run by Ty Johnson, the Ravens maintained control throughout the game. Henry's explosive performance showcased his remarkable speed, reaching a top speed of 21.29 miles per hour during his record-setting run. The Ravens will next face the Cincinnati Bengals in Week 5.