Louisville Opens ACC Play as Road Favorite Against Pittsburgh

The Louisville Cardinals football team is set to open their ACC schedule with a road game against the Pittsburgh Panthers at Acrisure Stadium. Louisville enters the game as the favorite, with odds ranging from 3.5 to 6.5 points in their favor and a 57% chance of winning according to ESPN's Football Power Index. The Cardinals, currently 3-0 for the third consecutive season, have shown a strong start but have yet to play a road game this season. Pittsburgh, holding a 2-1 record and coming off a bye week after an overtime loss to West Virginia, is expected to present a tough challenge, especially at home where Louisville has historically struggled, going 0-3 against Pitt since joining the ACC. Louisville’s offense, led by All-American running back Isaac Brown, is anticipated to focus on the run game to exploit Pittsburgh's defense, which has shown vulnerabilities against strong rushing attacks. Fans and analysts alike expect a competitive game, with Louisville aiming to maintain their undefeated start and establish momentum in conference play.