The Los Angeles Rams have started the season 0-2 for the first time since 2011, following a significant 41-10 loss to the Arizona Cardinals, marking their worst defeat under coach Sean McVay. The Rams are grappling with extensive injury issues affecting key players, including both top receivers and their entire offensive line, as they prepare to face their rivals, the San Francisco 49ers. In a controversial decision, the Rams traded linebacker Ernest Jones to the Titans for a future draft pick, which has raised questions about their defensive depth after struggling against the Cardinals. The 49ers, coming off a loss themselves, look to capitalize on the Rams' vulnerabilities, having historically dominated their recent matchups. Meanwhile, the Cardinals celebrated their first win of the season, showcasing strong performances from Kyler Murray and rookie Marvin Harrison Jr. This precarious situation for the Rams echoes the struggles of their last season, where they finished with a disappointing 5-12 record.