Cardinals RB James Conner Out Entire 2025 NFL Season Due Foot Injury

James Conner, the Arizona Cardinals' veteran running back, will miss the remainder of the 2025 NFL season due to a severe right foot injury sustained during a game against the San Francisco 49ers. Originally thought to be an ankle injury, it was later clarified that Conner requires surgery on his foot, ending his back-to-back 1,000-yard seasons and leaving a significant void in the Cardinals' offense. Head coach Jonathan Gannon expressed confidence in the team's ability to adjust despite Conner's absence, highlighting the contributions of second-year running back Trey Benson, who is expected to take over the starting role. Conner has been a consistent and emotional leader for Arizona, rushing for over 3,700 yards and 38 touchdowns in his time with the team. The injury occurred during a narrow 16-15 loss to the 49ers, marking Arizona's first defeat of the season with a current record of 2-1. Despite the setback, the Cardinals remain optimistic about correcting their offensive struggles and maintaining competitiveness as they prepare to face the Seattle Seahawks.