The Los Angeles Chargers face significant challenges ahead of their Week 2 matchup against the Carolina Panthers, primarily due to injuries to key defensive players, including linebacker Joey Bosa and safety Alohi Gilman. Bosa, who recorded seven tackles and a sack in the season opener against the Raiders, has been downgraded from a limited participant to not practicing at all due to a back injury. Meanwhile, Gilman missed practice entirely this week due to a knee injury, raising concerns about the depth of the Chargers' defense. Jesse Minter, the Chargers' defensive coordinator, emphasized the importance of player rotation to maintain freshness on the field, but injuries may complicate this strategy. Despite the setbacks, the Chargers have demonstrated depth with multiple players able to step up, including Khalil Mack and rookies Junior Colson and Denzel Perryman. As the team prepares for the Panthers, they will have to navigate these injury concerns while aiming to maintain their defensive performance.