Los Angeles Rams wide receiver Cooper Kupp is facing an extended absence due to an ankle injury sustained during the team's 41-10 loss to the Arizona Cardinals. Head coach Sean McVay indicated that Kupp could be placed on injured reserve, which would require him to miss at least four games. Kupp was seen limping off the field after a 24-yard catch in the first half, and despite initial hopes, the injury is significant. This injury compounds the Rams' challenges, with fellow receiver Puka Nacua also sidelined. The team's offensive depth is now further tested with Kupp's absence, as they prepare for a critical matchup against the 49ers while starting the season 0-2. Kupp's extensive injury history raises concerns about his recovery and impact on the team's performance moving forward.