In a tightly contested matchup, the San Diego Padres lost to the St. Louis Cardinals 4-3, ending their three-game winning streak. Nolan Arenado's walk-off single in the ninth inning secured the victory for the Cardinals, capitalizing on missed opportunities by the Padres, who failed to score with a runner on second and no outs in the final frame. Despite solid defensive plays from Manny Machado and others, the Padres couldn't overcome a three-run fourth inning by the Cardinals. Jake Cronenworth contributed with a stolen base and a run scored but fell short in the clutch moments. The loss dropped the Padres further behind in the National League West standings, now four games behind the Dodgers. Earlier in the series, the Padres had won 7-5, with Cronenworth delivering a key go-ahead hit to secure that win.