Los Angeles Rams' head coach Sean McVay announced that star wide receiver Cooper Kupp and left guard Jonah Jackson will miss extended time due to injuries sustained in a recent loss to the Arizona Cardinals. Kupp, who has a history of ankle injuries, may be placed on injured reserve, which would sideline him for at least four games. He had previously been a key player for the Rams but has struggled with injuries over the last few seasons. Additionally, safety John Johnson III is set to miss multiple weeks with a shoulder injury, adding to the team's injury woes. The Rams are already without several other key players, including fellow receiver Puka Nacua and multiple offensive linemen. As a result, the team's roster is significantly depleted ahead of their upcoming game against the San Francisco 49ers.