The Detroit Lions (2-1) are set to host the undefeated Seattle Seahawks (3-0) on Monday Night Football, with the Lions favored by 3.5 points despite a challenging matchup against a strong Seahawks defense. The Lions’ offense, led by Jared Goff, faces struggles due to injuries, notably missing All-Pro center Frank Ragnow, while the Seahawks, under rookie head coach Mike Macdonald, are also dealing with several defensive injuries. This game is critical for playoff seeding, making it a must-win for both teams, with the Lions looking to break a 12-year winless streak against Seattle. Key players to watch include Lions' David Montgomery and Amon-Ra St. Brown, as well as Seahawks' Kenneth Walker III and DK Metcalf. Betting analysts are leaning heavily towards the Lions, with 85% predicting their victory, despite the Seahawks' perfect record against teams with losing records. The matchup promises to be a significant test for both teams as they aim for playoff positioning.