In an exciting home opener, the Minnesota Vikings led by Sam Darnold defeated the San Francisco 49ers, with a standout 97-yard touchdown pass to Justin Jefferson. This win extended the 49ers' losing streak in Minnesota, where they haven't won since 1992. The 49ers, who dominated the New York Jets in Week 1, faced challenges without star running back Christian McCaffrey. San Francisco's Nick Bosa acknowledged the Vikings as a tougher opponent than the Jets, highlighting their strong run game and solid offensive tackles. The Vikings' defense also capitalized on aggressive blitzes, testing former 49ers QB Darnold's adaptability.