First West Nile Virus Case Confirmed in Louisville 2025

The first human case of West Nile virus in 2025 has been confirmed in Louisville, Kentucky, marking the first such case after multiple mosquitoes tested positive for the virus in various neighborhoods. Louisville's Chief Health Strategist, Connie Mendel, emphasized ongoing efforts to reduce mosquito populations year-round and urged residents to protect themselves by using insect repellents, wearing long clothing, and eliminating standing water to prevent mosquito breeding. While most infected individuals show no symptoms or only mild symptoms, less than 1% develop serious neurologic illnesses, with people over 60 and those with certain medical conditions at higher risk. Mosquito fogging with low-toxicity insecticides has been conducted in affected areas to reduce transmission risk. Health officials continue to advise precautions especially during peak mosquito-biting times at dawn and dusk, and recommend repairing window and door screens to keep mosquitoes out of homes. No deaths related to the virus have been reported in 2025 to date, but previous years have seen cases and fatalities, underscoring the importance of vigilance.