The Buffalo Bills rallied from a 14-point deficit to secure a 34-28 victory over the Arizona Cardinals in their season opener, highlighted by quarterback Josh Allen's four touchdowns, including two rushing. Allen completed 18 of 23 passes for 232 yards and demonstrated resilience, despite playing with a heavily wrapped non-throwing hand. The Cardinals initially took control with a strong start, including a touchdown pass from Kyler Murray and a rushing score from James Conner, but could not maintain their momentum. Buffalo's defense, led by Greg Rousseau's three sacks, was pivotal in stalling the Cardinals' offense in the second half. A standout moment included DeeJay Dallas's 96-yard kickoff return for a touchdown, marking the first such score under new NFL rules. The win marked a thrilling comeback for the Bills, showcasing their ability to adjust and overcome early mistakes.