Eric Dane Joins NBC's Brilliant Minds Season 2 as ALS-Afflicted Firefighter

Eric Dane, who publicly revealed his ALS diagnosis earlier in 2025, is set to guest star in Season 2, Episode 9 of NBC's medical drama "Brilliant Minds." He will portray Matthew, a heroic firefighter grappling with sharing his ALS diagnosis with his family, a storyline paralleling Dane's real-life battle with the progressive neurodegenerative disease. "Brilliant Minds," inspired by neurologist Oliver Sacks' work, follows Dr. Oliver Wolf and his team as they explore neurological medical mysteries. Dane's casting highlights his advocacy for ALS patients and his continued acting career despite the challenges posed by the disease, including his use of a wheelchair and loss of function in his right arm. The episode, airing November 24, 2025, promises an authentic portrayal of ALS's impact on patients and their families, underscoring the show's commitment to medically grounded storytelling. Dane is also reprising his role on HBO's "Euphoria" and remains active in his career while raising awareness about ALS.