Detroit Lions linebacker Derrick Barnes is expected to miss a significant amount of time due to a knee injury sustained during the second quarter of Sunday's game against the Arizona Cardinals. Head coach Dan Campbell confirmed that Barnes will likely be placed on injured reserve as the team seeks second opinions on his condition. In Barnes' absence, Jack Campbell and Malcolm Rodriguez are expected to step up in the linebacker role. Additionally, the Lions were already without starting linebacker Alex Anzalone, who was inactive due to a concussion. Cornerback Terrion Arnold also experienced a knee injury but managed to return to the game. The Lions' defense is now dealing with multiple injuries, impacting their depth significantly.