Seahawks Favored Over Cardinals in Week 4

Week 4 Thursday Night Football pits the 2-1 Seattle Seahawks at the 2-1 Arizona Cardinals on Thursday at State Farm Stadium (kickoff 8:15 p.m. ET), with the market pricing the game at about a 1.5-point spread and an over/under near 43.5. Arizona will be without RB James Conner (out for the season), elevating his replacement Benson and shaping several player-prop markets. Seattle brings a strong run game and defense, Jaxson Smith-Njigba has emerged as their leading receiver, and the Seahawks have won seven straight against Arizona since 2022, including a recent 44-13 victory. Kyler Murray has been efficient this season but has historically struggled against division rivals and the Seahawks in particular, a factor that could magnify Arizona’s offensive challenges. Oddsmakers, analysts (including Jon Gruden) and betting experts note the tight lines and sportsbook promos, with several handicappers leaning toward Seattle; bettors are reminded that odds can change and to gamble responsibly.