49ers vs Patriots: Injuries and Key Players

The San Francisco 49ers are dealing with multiple injuries as they prepare to face the New England Patriots, with tight end George Kittle set to return and receiver Deebo Samuel questionable. The team has suffered back-to-back losses and is in desperate need of a win to get back on track. The Patriots, under a first-year coach, have also struggled, ranking near the bottom of the league in offensive performance. Oddsmakers have made the 49ers significant favorites despite their injury woes. Key players to watch include 49ers' quarterback Brock Purdy and Patriots' running back Rhamondre Stevenson, with both teams looking to exploit their opponent's weaknesses.