Study Finds Key Genes Affecting Menopause Age

Recent research has identified four significant genes—ETAA1, ZNF518A, PNPLA8, and PALB2—that influence the timing of menopause, potentially causing it to occur 2 to 5.5 years earlier in women with only one functioning copy. This study, conducted by researchers from Exeter and Cambridge and published in Nature, analyzed data from over 106,000 postmenopausal women and revealed that these genetic changes are linked to increased risks of ovarian and breast cancer. Specifically, the ZNF518A variant was associated with menopause occurring 5.5 years earlier and is rare, found in 1 in 4,000 women. The findings underscore the importance of genetic factors in menopause timing, which can significantly affect women's life and career planning. The researchers emphasize that understanding these genetic mechanisms may lead to potential therapies to extend reproductive lifespan and address related health issues. Overall, this study opens new avenues for research into reproductive health and disease prevention.